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You are watching: Topamax for borderline personality disorder
Top of web page Study description Study style Arms and also Interventions Outcome measures Eligibility Criteria Contacts and also Locations more Information
The objective of the current study is to evaluate the efficacy of topiramate (250mg/day) versus placebo in decreasing aggression and reducing alcohol usage in patients with borderline personality disorder (BPD) and alcohol dependency (AD).
|Alcohol dependence Borderline Personality Disorder||Drug: Topiramate||phase 3|
Background: Borderline personality disorder (BPD) affects around 2% of the American adult population. That is a very serious psychiatric disorder the places hefty demands ~ above mental health resources. Habits dysregulation (impulsivity, self-injurious acts, drink or wild behavior) is taken into consideration one of the main functions of BPD and is linked with far-reaching clinical morbidity. Alcohol abuse is common among patients v BPD, and also the co-morbid prices of alcoholism in BPD patients are estimated to it is in 30%. It has been hypothesized the alcohol misuse might be a manifestation that BPD\"s behavior dysregulation. Also, BPD and alcohol dependence (AD) re-publishing a common underlying neurobiology. The co-occurrence of these disorders has been linked with increased rates that alcohol relapse, impulsive behaviors, greater resistance to treatment, and suicidal behavior. Efficient treatment because that patients v BPD and advertisement would result in markedly diminished health care costs and a substantial reduction in human being distress and suffering. Despite dramatic breakthroughs in the treatment of BPD, to date, no solitary medication or species of medications have actually been uniquely established as efficient in treating BPD. Researches treating patients v co-morbid BPD and ad are specifically lacking.
Research Design and Methodology: This is an 8-week double-blind outpatient clinical trial of dental topiramate (250mg) vs placebo in people with BPD and AD. The study will be conducted at the West Haven, CT VA. Thirty men and also women v a current diagnosis the BPD and ad will be enrolled. The State-Trait rage Expression list (STAEI) will certainly be used to evaluate 5 facets of aggression: state anger, properties anger, rage expressed inwardly, fury expressed outwardly, and anger control before and during treatment (weeks 0-8). The Timeline Follow-Back (TLFB) method will be used to paper the level of daily alcohol intake before and during therapy (90 days before treatment, and also weeks 0 - 8). Emergent side results will it is in assessed utilizing the modified variation of the organized Assessment for treatment Emergent events (SAFTEE).
Top of page Study summary Study design Arms and also Interventions Outcome actions Eligibility Criteria Contacts and Locations much more Information
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|Study form :||Interventional (Clinical Trial)|
|ActualEnrollment :||0 participants|
|Intervention Model:||Factorial Assignment|
|Masking:||Triple (Participant, care Provider, Investigator)|
|Official Title:||Topiramate for therapy of Patients v Borderline Personality Disorder and Alcohol Dependence|
|study Start date :||March 2007|
|Actual major Completion date :||May 2009|
|Actual study Completion day :||May 2009|